Hatton, C.F., Botting, R.A., Dueñas, M.E. et al. Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2. Nat Commun 12, 7092 (2021). https://doi.org/10.1038/s41467-021-27318-0 Rutherford HA, Kasher PR, Hamilton N. Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy. Front Immunol. (2021);11:623650. doi: 10.3389/fimmu.2020.623650. Yang C, Georgiou M, Atkinson R, Collin J, Al-Aama J, Nagaraja-Grellscheid S, Johnson C, Ali R, Armstrong L, Mozaffari-Jovin S, Lako M. Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond. Front Cell Dev Biol. 2021 Jul 28;9:700276. doi: 10.3389/fcell.2021.700276 Lennie, E., Tsoumpas, C. & Sourbron, S. Multimodal phantoms for clinical PET/MRI. EJNMMI Phys 8, 62 (2021). https://doi.org/10.1186/s40658-021-00408-0 Solis-Castro Oscar O., Wong Natalie, Boissonade Fiona M. Chemokines and Pain in the Trigeminal System. Front. Pain Res., 2021 July; 2:31 DOI: https://doi.org/10.3389/fpain.2021.689314 Hammond S, Olsson-Brown A, Gardner J, Thomson P, Ali SE, Jolly C, Carr D, Ressel L, Pirmohamed M, Naisbitt D. T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. J Immunother Cancer. 2021 May;9(5):e002521. doi: 10.1136/jitc-2021-002521. Varn, F., Johnson, K., Barthel, F., Kim, H., Wade, T., Malta, T., Sabedot, T., Lodha, D., Ajaib, S., Ahmed, N., Garofano, L., D’Angelo, F., Stead, L., Poisson, L., Noushmehr, H., Iavarone, A., Verhaak, R., & GLASS Consortium (2021). OMRT-3. Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment. Neuro-oncology Advances, 3 (Suppl 2), ii7–ii8. https://doi.org/10.1093/noajnl/vdab070.029 Varn, F., Johnson, K., Barthel, F., Kim, H., Wade, T., Lodha, D., Ajaib, S., Ahmed, N., Garofano, L., D'Angelo, F., Stead, L., Noushmehr, H., Varone, A. and Verhaak, R. (2020). EPCO-08. TUMOR-IMMUNE INTERACTIONS ARE DYNAMIC AND INFLUENCE THE EVOLUTIONARY TRAJECTORY OF ADULT DIFFUSE GLIOMA. Neuro-Oncology. 22. ii70-ii71. DOI: https://doi.org/10.1093/neuonc/noaa215.287 George E. Stenhouse, Khuzwayo C. Jere, Chikondi Peno, Rebecca J. Bengtsson, End Chinyama, Jonathan Mandolo, Amy Cain, Miren Iturriza-Gómara, Naor Bar-Zeev, Nigel A. Cunliffe, Jennifer Cornick and Kate S. Baker (2021) Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance Microbial Genomics;7:000532 DOI 10.1099/mgen.0.000532 Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury. FASEB J. 2021 May;35(5):e21604. doi: 10.1096/fj.202100240R Jonathon Alexis Coates, Elliot Brooks, Amy Louise Brittle, Emma Louise Armitage, Martin Peter Zeidler, Iwan Robert Evans, 'Identification of functionally distinct macrophage subpopulations in Drosophila' eLife doi: 10.7554/eLife.58686 Joshua A. F. Sutton, Oliver T. Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F. Gibson, Eric J. G. Pollitt, Simone C. Tazoll, William Turnbull, Natalia H. Hajdamowicz, Bartłomiej Salamaga, Grace R. Pidwill, Alison M. Condliffe, Stephen A. Renshaw, Waldemar Vollmer, Simon J. Foster. Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. Plos Pathogens doi: 10.1371/journal.ppat.1009468 Clancy,A, Heride,C. Pinto-Fernández,A., Elcocks,H., Kallinos,A., Kayser-Bricker,K.J., Wang, W., Smith,V., Davis,S., Fessler,S., McKinnon,C., Katz,M., Hammonds,T., Jones, N.P., O’Connell,J., Follows,B., Mischke,S., Caravella,J.A., Ioannidis,S., Dinsmore,C., Kim, S., Behrens,A., Komander,D., Kessler,B.M., Urbé,S, Clague,M.J. (2021) The deubiquitylase USP9X controls ribosomal stalling. J. Cell Biol. 220 (3): e202004211, doi: 10.1083/jcb.202004211 Olivier R. Tardy, Emma L. Armitage, Lynne R. Prince, Iwan R. Evans. The Epidermal Growth Factor Ligand Spitz Modulates Macrophage Efferocytosis, Wound Responses and Migration Dynamics During Drosophila Embryogenesis Front. Cell Dev. Biol. doi:10.3389/fcell.2021.636024 Mengoli V, Jonak K, Lyzak O, Lamb M, Lister LM, Lodge C, Rojas J, Zagoriy I, Herbert M, Zachariae W. Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension. EMBO J. 2021 Apr 1;40(7):e106812. DOI: 10.15252/embj.2020106812 Serat-E Ali as part of the COVID-LIV Study Group. Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BJM Open doi:10.1136/bmjopen-2020-048317 Snodgrass RO, Chico TJA, Arthur HM. Hereditary Haemorrhagic Telangiectasia, an Inherited Vascular Disorder in Need of Improved Evidence-Based Pharmaceutical Interventions. Genes (Basel). 2021 Jan 27;12(2):174. doi: 10.3390/genes12020174 Castanheira, C., Balaskas, P., Falls, C. et al. Equine synovial fluid small non-coding RNA signatures in early osteoarthritis. BMC Vet Res 17, 26 (2021). https://doi.org/10.1186/s12917-020-02707-7 Kreilkamp BAK, McKavanagh A, Alonazi B, Bryant L, Das K, Wieshmann UC, Marson AG, Taylor PN, Keller SS. Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance. Neuroimage Clin.2021;29:102564. doi: 10.1016/j.nicl.2021.102564. Ane Ogbe, Barbara Kronsteiner, Donal T. Skelly, Matthew Pace, Anthony Brown, Emily Adland, Kareena Adair, Hossain Delowar Akhter, Mohammad Ali, Serat-E Ali, Adrienn Angyal, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Helen Brown, Senthil Chinnakannan, Christopher Conlon, Catherine de Lara, Thushan de Silva, Christina Dold, Tao Dong, Timothy Donnison, David Eyre, Amy Flaxman, Helen Fletcher, Joshua Gardner, James T. Grist, Carl-Philipp Hackstein, Kanoot Jaruthamsophon, Katie Jeffery, Teresa Lambe, Lian Lee, Wenqin Li, Nicholas Lim, Philippa C. Matthews, Alexander J. Mentzer, Shona C. Moore, Dean J. Naisbitt, Monday Ogese, Graham Ogg, Peter Openshaw, Munir Pirmohamed, Andrew J. Pollard, Narayan Ramamurthy, Patpong Rongkard, Sarah Rowland-Jones, Oliver Sampson, Gavin Screaton, Alessandro Sette, Lizzie Stafford, Craig Thompson, Paul J. Thomson, Ryan Thwaites, Vinicius Vieira, Daniela Weiskopf, Panagiota Zacharopoulou, Oxford Immunology Network Covid-19 Response T Cell Consortium, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team, Lance Turtle, Paul Klenerman, Philip Goulder, John Frater, Eleanor Barnes & Susanna Dunachie (2021) T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses Nature Communications doi:10.1038/s41467-021-21856-3 Lorna Bryant, Emilie T. McKinnon, James A. Taylor, Jens H. Jensen, Leonardo Bonilha, Christophe de Bezenac, Barbara A. K. Kreilkamp, Guleed Adan, Udo C. Wieshmann, Shubhabrata Biswas, Anthony G. Marson, Simon S. Keller. Fiber ball white matter modeling in focal epilepsy Human Brain Mapping doi: 10.1002/hbm.25382 Adam Albanese, Leonard A. Daly, Daniela Mennerich, Thomas Kietzmann, Violaine Sée. The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity Int. J. Mol. Sci. 2021, 22(1), 268; https://doi.org/10.3390/ijms22010268

Mawdesley A, Davidson L, Anjum S, Kirby J, Tyson-Capper A (2020) Effect of Cobalt Ions on Chemokine Expression: Case Report of Immune Cell Infiltration in Patient Undergoing Revision of Metal-On-Metal Implant. J Orthop Res Ther 5: 1154. DOI: 10.29011/2575-8241.001154 Adam J. Carlton, Julia Halford, Anna Underhill, Jing‐Yi Jeng, Matthew R. Avenarius, Merle L. Gilbert, Federico Ceriani , Kimimuepigha Ebisine, Steve D. M. Brown, Michael R. Bowl, Peter G. Barr‐Gillespie & Walter Marcotti. Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. J Physiol 599.4 (2021) pp 1173–1198 https://doi.org/10.1113/JP280670 Florian Gothe, Catherine F Hatton, Linh Truong, Zofia Klimova, Veronika Kanderova, Martina Fejtkova, Angela Grainger, Venetia Bigley, Joanna Perthen, Dipayan Mitra, Ales Janda, Eva Fronkova, Dusana Moravcikova, Sophie Hambleton, Christopher J A Duncan. A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis. Clinical Infectious Diseases, ciaa1790, https://doi.org/10.1093/cid/ciaa1790 Stephen R Knight, Antonia Ho, Riinu Pius, Iain Buchan, Gail Carson, Thomas M Drake, Jake Dunning, Cameron J Fairfield, Carrol Gamble, Christopher A Green, Rishi Gupta, Sophie Halpin, Hayley E Hardwick, Karl A Holden, Peter W Horby, Clare Jackson, Kenneth A Mclean, Laura Merson, Jonathan S Nguyen-Van-Tam, Lisa Norman, Mahdad Noursadeghi, Piero L Olliaro, Mark G Pritchard, Clark D Russell, Catherine A Shaw, Aziz Sheikh, Tom Solomon, Cathie Sudlow, Olivia V Swann, Lance CW Turtle, Peter JM Openshaw, Kenneth Baillie, Malcolm G Semple, Annemarie B Docherty, Ewen M Harrison, on behalf of the ISARIC4C investigators Including Robyn Kiy & Rebekah Penrice-Randal (2020) Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m3339 Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom & Laura C. Greaves ‘Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis’ – ‘Nature Cancer’ doi:10.1038/s43018-020-00112-5 Lodge C, Herbert M. Oocyte aneuploidy-more tools to tackle an old problem. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):11850-11852 DOI: 10.1073/pnas.2005739117 Pei G. Chew, Peter P. Swoboda, Carrie Ferguson, Pankaj Garg, Abigail L. Cook, Said Ibeggazene, Louise A. E. Brown, Thomas P. Craven, James R. Foley, Graham J. Fent, Christopher E. Saunderson, David M. Higgins, Sven Plein, Karen M. Birch, John P. Greenwood ‘Feasibility and reproducibility of a cardiovascular magnetic resonance free-breathing, multi-shot, navigated image acquisition technique for ventricular volume quantification during continuous exercise. QIMS doi: 10.21037/qims-20-117 David A. Dorward, Clark D. Russell, In Hwa Um, Mustafa Elshani, Stuart D. Armstrong, Rebekah Penrice-Randal, Tracey Millar, Chris E. B. Lerpiniere, Giulia Tagliavini, Catherine S. Hartley, Nadine P. Randle, Naomi N. Gachanja, Philippe M. D. Potey, Xiaofeng Dong, Alison M. Anderson, Victoria L. Campbell, Alasdair J. Duguid, Wael Al Qsous, Ralph BouHaidar, J. Kenneth Baillie, Kevin Dhaliwal, William A. Wallace, Christopher O. C. Bellamy, Sandrine Prost, Colin Smith, Julian A. Hiscox, David J. Harrison, Christopher D. Lucas ‘Tissue-Specific Immunopathology in Fatal COVID-19’ – ‘American Journal of Respiratory and Critical Care Medicine’ doi: 10.1164/rccm.202008-3265OC Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. Caisey V. Pulford, Blanca M. Perez-Sepulveda, Rocío Canals, Jessica A. Bevington, Rebecca J. Bengtsson, Nicolas Wenner, Ella V. Rodwell, Benjamin Kumwenda, Xiaojun Zhu, Rebecca J. Bennett, George E. Stenhouse, P. Malaka De Silva, Hermione J. Webster, Jose A. Bengoechea, Amy Dumigan, Alicia Tran-Dien, Reenesh Prakash, Happy C. Banda, Lovemore Alufandika, Mike P. Mautanga, Arthur Bowers-Barnard, Alexandra Y. Beliavskaia, Alexander V. Predeus, Will P. M. Rowe, Alistair C. Darby, Neil Hall, François-Xavier Weill, Melita A. Gordon, Nicholas A. Feasey, Kate S. Baker, Jay C. D. Hinton ‘Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa’ – ‘Nature Microbiology’ doi: 10.1038/s41564-020-00836-1 Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong,1, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod ‘Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites’ – ‘Front Cell Infect Microbiol’ doi: 10.3389/fcimb.2020.00203 Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randalld, Daniel Erskine, Christopheer M.Morris, Amy K.Reeve, Gavin J.Clowry, Fiona E.N. LeBeaua‘Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein’ – Neurobiology of Disease doi: 10.1016/j.nbd.2020.105226 George E. Stenhouse, Khuzwayo C. Jere, Chikondi Peno, Rebecca J. Bengtsson, End Chinyama, Jonathan Mandolo, K. Cain, Miren Iturriza-Gómara, Naor Bar-Zeev, Nigel A. Cunliffe, Jennifer Cornick, Kate S. Baker 'Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance. bioRxiv 2020 doi: https://doi.org/10.1101/2020.11.20.391235 Mandy J. Peffers, Alzbeta Chabronova, Panagiotis Balaskas, Yongxiang Fang, Philip Dyer, Andy Cremers, Pieter J. Emans, Peter Z. Feczko, Marjolein M. Caron & Tim J. M. Welting SnoRNA signatures in cartilage ageing and osteoarthritis. Scientific Reports doi: 10.1038/s41598-020-67446-z Panagiotis Balaskas, Jonathan A. Green, Tariq M. Haqqi, Philip Dyer, Yalda A. Kharaz, Yongxiang Fang, Xuan Liu, Tim J.M. Welting, Mandy J. Peffers, ‘Small Non-Coding RNAome of Ageing Chondrocytes’ – ‘Int. J. Mol. Sci’ doi:10.3390/ijms21165675 Shona C. Moore, Rebekah Penrice-Randal, Muhannad Alruwaili, Nadine Randle, Stuart Armstrong, Catherine Hartley, Sam Haldenby, Xiaofeng Dong, Abdulrahman Alrezaihi, Mai Almsaud, Eleanor Bentley, Jordan Clark, Isabel García-Dorival, Paul Gilmore, Ximeng Han, Benjamin Jones, Lisa Luu, Parul Sharma, Ghada Shawli, Yani Sun, Qin Zhao, Steven T. Pullan, Daniel P. Carter, Kevin Bewley, Jake Dunning, En-min Zhou, Tom Solomon, Michael Beadsworth, James Cruise, Derrick W. Crook, David A. Matthews, Andrew D. Davidson, Zana Mahmood, Waleed Aljabr, Julian Druce, Richard Vipond, Lisa Ng, Laurent Renia, Peter J. M. Openshaw, J. Kenneth Baillie, Miles W. Carroll, James Stewart, Alistair Darby, Malcolm Semple, Lance Turtle, Julian A. Hiscox ‘Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism’ – ‘Viruses’ doi: 10.3390/v12101164 Adam J Carlton, Julia Halford, Anna Underhill, Jing-Yi Jeng, Matthew R Avenarius, Merle L Gilbert, Federico Ceriani, Kimimuepigha Ebisine, Steve D M Brown, Michael R Bowl, Peter G Barr-Gillespie, Walter Marcotti Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness – ‘J Physiol’ doi: 10.1113/JP280670 Philip AJ Crosbie, Rhian Gabe, Irene Simmonds, Martyn Kennedy, Suzanne Rogerson, Nazia Ahmed, David R Baldwin, Richard Booton, Ann Cochrane, Michael Darby, Kevin Franks, Sebastian Hinde, Sam M Janes, Una Macleod, Mike Messenger, Henrik Moller, Rachael L Murray, Richard D Neal, Samantha L Quaife, Mark Sculpher, Puvanendran Tharmanathan, David Torgerson, Matthew EJ Callister 'Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk' 'BMJ Open' doi: 10.1136/bmjopen-2020-037075 Alexander G. Bury, Amy E. Vincent, Doug M. Turnbull, Paolo Actis, Gavin Hudson (2020) Mitochondrial isolation: when size matters – ‘Wellcome Open Res’ doi: https://doi.org/10.12688/wellcomeopenres.16300.2 Phillippa J Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, Wenbin Wei, Chris Hastings, Siew Wong, Christine Lo, Samuel Evetts, Hannah Clemmens, Matthew Wyles, Sam Willcox, Thomas Payne, Rachel Hughes, Laura Ferraiuolo, Caleb Webber, Winston Hide, Richard Wade-Martins, Kevin Talbot, Michele T Hu, Oliver Bandmann 'Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease' – ‘Prog Neurobiol’ doi: 10.1016/j.pneurobio.2020.101772 Elisa Molinari, Shalabh Srivastava, Rebecca M. Dewhurst, John A. Sayer 'Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles' – ‘BMC Nephrology’ doi:10.1186/s12882-020-02094-z. Grace Mallett, Warren Patterson, Megan Payne, Shoba Amarnath 'Isolation and Characterization of Innate Lymphoid Cells within the Murine Tumor Microenvironment' – ‘MIMB, volume 2121’ doi: 10.1007/978-1-0716-0338-3_14 Madeleine R. Brown, Sheena E. Radford, Eric W. Hewitt 'Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection' – ‘Frontiers in Molecular Neuroscience’ doi: 10.3389/fnmol.2020.609073 Andrea C Masi, Yaa E A Oppong, Beate Haugk, Christopher A Lamb, Linda Sharp, James M Shaw, Christopher J Stewart, Kofi W Oppong 'Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) formalin fixed paraffin-embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis' -'Gut' doi:10.1136/gutjnl-2020-322457 James C. Waddington, Serat-E Ali, Sophie L. Penman, Paul Whitaker, Jane Hamlett, Amy Chadwick, Dean J. Naisbitt, B. Kevin Park, Xiaoli Meng 'Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury' - 'Chemical Research in Toxicology' doi:10.1021/acs.chemrestox.0c00400 Alexander G. Bury, Amy E. Vincent, Doug M. Turnbull, Paolo Actis, Gavin Hudson 'Mitochondrial Isolation: when size matters' - 'Wellcome Open Research' doi:10.12688/wellcomeopenres.16300.1 Katherine A. Davies, Benjamin Chadwick, Roger Hewson, Juan Fontana, Jamel Mankouri, John N. Barr 'The RNA Replication Site of Tula Orthohantavirus Resides within a Remodelled Golgi Network' - 'Cells' doi:10.3390/cells9071569 Viralkumar V. Panchal, Caitlin Griffiths, Hamed Mosaei, Bohdan Bilyk, Joshua A. F. Sutton, Oliver T. Carnell, David P. Hornby, Jeffrey Green, Jamie K. Hobbs, William L. Kelley, Nikolay Zenkin, Simon J. Foster - 'Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression' - 'Plos Pathogens' doi:10.1371/journal.ppat.1008672 Rebecca Marie Dewhurst, Annachiara Scalzone, Joseph Buckley, Clara Mattu, Kenneth S. Rankin, Piergiorgio Gentile, Ana Marina Ferreira 'Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release' -'Front. Bioeng. Biotechnol.' doi :10.3389/fbioe.2020.00754 Thomas M.D. Sheard, Luke Howlett, Hannah Kirton, Zhaokang Yang, Georgina Gurrola, Derek Steele, Izzy Jayasinghe, Hector H. Valdivia, John Colyer 'Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes' - 'bioRxiv - Preprint Server for Biology': doi: 10.1101/2020.06.26.131854 Catherine M. Buckley, Henderikus Pots, Aurelie Gueho, James H. Vines, Christopher J. Munn, Ben A. Phillips, Bernd Gilsbach, David Traynor, Anton Nikolaev, Thierry Soldati, Andrew J. Parnell, Arjan Kortholt, and Jason S. King 'Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria' - 'Current Biology': doi:https://doi.org/10.1016/j.cub.2020.05.049 Bartoli, F., Bailey, M. A., Rode, B., Mateo, P., Antigny, F., Bedouet, K., Gerbaud, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Ainscough, J. F. X., Kearney, M. T., Bruns, A.-F., Shi, J., Appleby, H. L., Young, R. S., Shawer, H. M., Debant, M., Gomez, A.-M., Beech, D. J., Foster, R., Benitah, J.-P. and Sabourin, J. (2020) ‘Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload’, 'Circulation'. doi: 10.1161/CIRCULATIONAHA.118.038891. Devlin, L. A., Ramsbottom, S. A., Overman, L. M., Lisgo, S. N., Clowry, G., Molinari, E., Powell, L., Miles, C. G. and Sayer, J. A. (2020) ‘Embryonic and foetal expression patterns of the ciliopathy gene CEP164’ - 'PLOS ONE' doi: 10.1371/journal.pone.0221914. Matthew J. Burke, Peter G. Stockley, and Joan Boyes. 'Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?' - 'Viruses' doi: 10.3390/v12040473 Andrea C Masi, Sara Koo, Christopher A Lamb ,Mark A Hull, Linda Sharp, Andrew Nelson, James S Hampton, Colin J Rees, Christopher J Stewart. 'Using faecal immunochemical test (FIT) undertaken in a national screening programme for large-scale gut microbiota analysis' - 'GUT' doi:10.1136/gutjnl-2020-321594

Lauren Tomlinson, Zhen Qi Lub, Robert A Bentley, Helen E.Colley, Craig Murdoch, Steven D.Webb, Michael J.Cross, Ian M. Copple, Parveen Sharmaa ‘Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway’ – ‘Biomedicine & Pharmacotherapy’ doi: 10.1016/j.biopha.2019.108637 Lauren J. Tomlinson, Alice K. M. Clubbs Coldron, Patrick A. Eyers, Claire E. Eyers ‘Determination of Phosphohistidine Stoichiometry in Histidine Kinases by Intact Mass Spectrometry’ – ‘MIMB, volume 2077’ doi: 10.1007/978-1-4939-9884-5_6 Lauren Tomlinson, Lauren Hyndman, James W. Firman, Robert Bentley, Jonathan A. Kyffin, Steven D. Webb, Sean McGinty, Parveen Sharma ‘In vitro Liver Zonation of Primary Rat Hepatocytes’ – ‘Front. Bioeng. Biotechnol’ doi: 10.3389/fbioe.2019.00017 Thomas M. D. Sheard, Sanjay R. Kharche, Christian Pinali, Holly A. Shiels ‘3D ultrastructural organisation of calcium release units in the avian sarcoplasmic reticulum’ – ‘Journal of Experimental Biology’ doi: 10.1242/jeb.197640 Molinari, E., Ramsbottom, S. A., Srivastava, S., Booth, P., Alkanderi, S., McLafferty, S. M., Devlin, L. A., White, K., Gunay-Aygun, M., Miles, C. G. and Sayer, J. A. 'Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts' – ‘Scientific Reports’ doi:10.1038/s41598-019-47243-z. Ajuwon, V., Ali, S.-E., Ashra, N., Banas, C., Barasa, S., Bhalla, S. R., Chakrabarty, A., Elelu, N., Ha, K. P., Ihekwaba, N., Mirza, N., Said, S., Sarmin, A., Sarveswaran, N., Simon, A. and Vallath, S. (2019) ‘Workforce Diversity: Let’s talk about race’ - eLife, 12 April. Available at: https://elifesciences.org/inside-elife/313036d9/workforce-diversity-let-s-talk-about-race. Ali, S.-E., Waddington, J. C., Park, B. K. and Meng, X. (2019) ‘Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury’ - 'Chemical Research in Toxicology' doi: 10.1021/acs.chemrestox.9b00275. Allen, S. P., Hall, B., Castelli, L. M., Francis, L., Woof, R., Siskos, A. P., Kouloura, E., Gray, E., Thompson, A. G., Talbot, K., Higginbottom, A., Myszczynska, M., Allen, C. F., Stopford, M. J., Hemingway, J., Bauer, C. S., Webster, C. P., De Vos, K. J., Turner, M. R., Keun, H. C., Hautbergue, G. M., Ferraiuolo, L. and Shaw, P. J. (2019) ‘Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis’ - 'Brain, 142' (3), pp. 586–605. doi: 10.1093/brain/awy353. Allen, S. P., Hall, B., Woof, R., Francis, L., Gatto, N., Shaw, A. C., Myszczynska, M., Hemingway, J., Coldicott, I., Willcock, A., Job, L., Hughes, R. M., Boschian, C., Bayatti, N., Heath, P. R., Bandmann, O., Mortiboys, H., Ferraiuolo, L. and Shaw, P. J. (2019) ‘C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis’ - 'Brain', 142 (12), pp. 3771–3790. doi: 10.1093/brain/awz302. Bennison, D. J., Irving, S. E. and Corrigan, R. M. (2019) ‘The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly’ - 'Cells, 8'(11), p. 1313. doi: 10.3390/cells8111313. da Silva, B., Irving, B. K., Polson, E. S., Droop, A., Griffiths, H. B. S., Mathew, R. K., Stead, L. F., Marrison, J., Williams, C., Williams, J., Short, S. C., Scarcia, M., O’Toole, P. J., Allison, S. J., Mavria, G. and Wurdak, H. (2019) ‘Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells’ - 'Journal of Cell Science, 132'(19). doi: 10.1242/jcs.228452. Devlin, L. A. and Sayer, J. A. ‘Renal ciliopathies’, Current Opinion in Genetics & Development. (Molecular and genetic basis of disease), 56, pp. 49–60. doi: 10.1016/j.gde.2019.07.005. Duncan, C. J. A., Thompson, B. J., Chen, R., Rice, G. I., Gothe, F., Young, D. F., Lovell, S. C., Shuttleworth, V. G., Brocklebank, V., Corner, B., Skelton, A. J., Bondet, V., Coxhead, J., Duffy, D., Fourrage, C., Livingston, J. H., Pavaine, J., Cheesman, E., Bitetti, S., Grainger, A., Acres, M., Innes, B. A., Mikulasova, A., Sun, R., Hussain, R., Wright, R., Wynn, R., Zarhrate, M., Zeef, L. A. H., Wood, K., Hughes, S. M., Harris, C. L., Engelhardt, K. R., Crow, Y. J., Randall, R. E., Kavanagh, D., Hambleton, S. and Briggs, T. A. (2019) ‘Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2’ - 'Science Immunology' doi: 10.1126/sciimmunol.aav7501. Duncan, J. A., Foster, R. and Kwok, J. C. F. (2019) ‘The potential of memory enhancement through modulation of perineuronal nets’ - 'British Journal of Pharmacology' 176(18), pp. 3611–3621. doi: 10.1111/bph.14672. Hatton, C. F. and Duncan, C. J. A. (2019) ‘Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis’ - 'Frontiers in Immunology' doi: 10.3389/fimmu.2019.02656. Mallett G, Laurence A and Amarnath S (2019) 'Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid cells' - 'International Journal of Molecular Sciences' doi: 10.3390/ijms20112836 Manners, O., Baquero-Perez, B. and Whitehouse, A. (2019) ‘m6A: Widespread regulatory control in virus replication’, Biochimica et Biophysica Acta (BBA)' - 'Gene Regulatory Mechanisms. (mRNA modifications in gene expression control)', 1862(3), pp. 370–381. doi: 10.1016/j.bbagrm.2018.10.015. Masi A.C., Stewart C.J. (2019) ‘The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis’ - 'Early Hum Dev' doi: 10.1016/j.earlhumdev.2019.104854 Miles, J., Scherz-Shouval, R. and van Oosten-Hawle, P. (2019) ‘Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response’ - 'Trends in Biochemical Sciences' doi: 10.1016/j.tibs.2019.06.009. Molinari, E., Ramsbottom, S. A., Srivastava, S., Booth, P., Alkanderi, S., McLafferty, S. M., Devlin, L. A., White, K., Gunay-Aygun, M., Miles, C. G. and Sayer, J. A. (2019) ‘Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts’ - 'Scientific Reports' doi: 10.1038/s41598-019-47243-z. Powell, L., Samarakoon, Y. H., Ismail, S. and Sayer, J. A. (2019) ‘ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses’, Small GTPases, 0(0), pp. 1–10. doi: 10.1080/21541248.2019.1703466. Ramsbottom, S. A., Thelwall, P. E., Wood, K. M., Clowry, G. J., Devlin, L. A., Silbermann, F., Spiewak, H. L., Shril, S., Molinari, E., Hildebrandt, F., Gunay-Aygun, M., Saunier, S., Cordell, H. J., Sayer, J. A. and Miles, C. G. (2019) ‘Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome’, Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1912602117. Rudman, J., Evans, R. J. and Johnston, S. A. (2019) ‘Are macrophages the heroes or villains during cryptococcosis?’, Fungal Genetics and Biology, 132, p. 103261. doi: 10.1016/j.fgb.2019.103261. Thomas M D Sheard, Miriam E Hurley, John Colyer, Ed White, Ruth Norman, Eleftheria Pervolaraki, Kaarjel K Narayanasamy, Yufeng Hou, Hannah M Kirton, Zhaokang Yang, Liam Hunter, Jung-Uk Shim, Alexander H Clowsley, Andrew J Smith, David Baddeley, Christian Soeller, Michael A Colman, Izzy Jayasinghe 'Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease With Enhanced Expansion Microscopy', ACS Nano, doi: 10.1021/acsnano.8b08742. Souilhol, C., Gauci, I., Feng, S., Tardajos Ayllon, B., Mahmoud, M., Canham, L., Fragiadaki, M., Serbanovic-Canic, J., Ridger, V. and Evans, P. C. (2019) ‘Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites’, Cardiovascular Research, cvz235. doi: 10.1093/cvr/cvz235. Wood, A., Irving, S. E., Bennison, D. J. and Corrigan, R. M. (2019) ‘The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus’, PLOS Genetics, 15(8), p. e1008346. doi: 10.1371/journal.pgen.1008346. ​

Urszula L McClurg, Arash Nabbi, Charles Ricordel, Svitlana Korolchuk, Stuart McCracken, Rakesh Heer, Laura Wilson, Lisa M Butler, Bronwyn Kate Irving-Hooper, Rémy Pedeux, Craig N Robson, Karl T Riabowol & Olivier Binda Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein – ‘British Journal of Cancer’ doi:10.1038/bjc.2017.447 Adamson, K. I., Sheridan, E. and Grierson, A. J. (2018) ‘Use of zebrafish models to investigate rare human disease’, Journal of Medical Genetics, 55(10), pp. 641–649. doi: 10.1136/jmedgenet-2018-105358. Bansagi, B., Phan, V., Baker, M. R., O’sullivan, J., Jennings, M. J., Whittaker, R. G., Müller, J. S., Duff, J., Griffin, H. and Miller, J. A. (2018) ‘Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation’, Neurology, 90(21), pp. e1842–e1848. doi: 10.1212/WNL.0000000000005566. Bartoli, F., Bailey, M., Rode, B., Mateo, P., Gosain, R., Plante, J., Norman, K., Gomez, S., Lefebvre, F., Rucker-Martin, C., Gomez, A. M., Beech, D., Foster, R., Benitah, J. P. and Sabourin, J. (2018) ‘Orai1 channels inhibition protects the heart from pressure overload-induced ventricular dysfunction’, Journal of Molecular and Cellular Cardiology. (SI:Abstracts ISHR-ES Amsterdam), 120, p. 12. doi: 10.1016/j.yjmcc.2018.05.046. Boczonadi, V., Jennings, M. J. and Horvath, R. (2018) ‘The role of tRNA synthetases in neurological and neuromuscular disorders’, FEBS Letters, 592(5), pp. 703–717. doi: 10.1002/1873-3468.12962. Juneja, M., Azmi, A., Baets, J., Roos, A., Jennings, M. J., Saveri, P., Pisciotta, C., Bernard-Marissal, N., Schneider, B. L., Verfaillie, C., Chrast, R., Seeman, P., Hahn, A. F., Jonghe, P. de, Maudsley, S., Horvath, R., Pareyson, D. and Timmerman, V. (2018) ‘PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease’, Journal of Neurology, Neurosurgery & Psychiatry, 89(8), pp. 870–878. doi: 10.1136/jnnp-2017-317562. Manners, O., Murphy, J. C., Coleman, A., Hughes, D. J. and Whitehouse, A. (2018)‘Contribution of the KSHV and EBV lytic cycles to tumourigenesis’, Current Opinion in Virology. (Engineering for viral resistance - Viruses and cancer), 32, pp. 60–70. doi: 10.1016/j.coviro.2018.08.014. Muniyandi, S., Pangratiou, G., Edwards, T. A. and Barr, J. N. (2018) ‘Structure and Function of the Human Respiratory Syncytial Virus M2–1 Protein’, in Harris, J. R. and Bhella, D. (eds) Virus Protein and Nucleoprotein Complexes. Singapore: Springer (Subcellular Biochemistry), pp. 245–260. doi: 10.1007/978-981-10-8456-0_11. Peffers, M. J., Balaskas, P. and Smagul, A. (2018) ‘Osteoarthritis year in review 2017: genetics and epigenetics’, Osteoarthritis and Cartilage, 26(3), pp. 304–311. doi: 10.1016/j.joca.2017.09.009. Ramsbottom, S. A., Molinari, E., Srivastava, S., Silberman, F., Henry, C., Alkanderi, S., Devlin, L. A., White, K., Steel, D. H., Saunier, S., Miles, C. G. and Sayer, J. A. (2018) ‘Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model’, Proceedings of the National Academy of Sciences, 115(49), pp. 12489–12494. doi: 10.1073/pnas.1809432115. Rubaiy, H. N., Ludlow, M. J., Siems, K., Norman, K., Foster, R., Wolf, D., Beutler, J. A. and Beech, D. J. (2018) ‘Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels’, British Journal of Pharmacology, 175(16), pp. 3361–3368. doi: 10.1111/bph.14379. Selvaraj, M., Yegambaram, K., Todd, E. J. A. A., Richard, C.-A., Dods, R. L., Pangratiou, G. M., Trinh, C. H., Moul, S. L., Murphy, J. C., Mankouri, J., Éléouët, J.-F., Barr, J. N. and Edwards, T. A. (2018) ‘The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex’, mBio, 9(6). doi: 10.1128/mBio.01554-18. Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F A, Liniany L P, Knight D, Samsel L A, Berlinguer-Palmini R, Yim J J , Felizardo T C, Eckhaus M A, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler D H, Van Kasteren S I, Laurence A, Bogyo M, Watts C, Shevach E M and Amarnath S (2018) 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T cells' Immunity 49 (2) 247-263 ; doi: 10.1016/j.immuni.2018.05.006 ​

Allen, C. F., Shaw, P. J. and Ferraiuolo, L. (2017) ‘Can Astrocytes Be a Target for Precision Medicine?’, in El-Khamisy, S. (ed.) Personalised Medicine: Lessons from Neurodegeneration to Cancer. Cham: Springer International Publishing (Advances in Experimental Medicine and Biology), pp. 111–128. doi: 10.1007/978-3-319-60733-7_7. Balaskas, P., Goljanek-Whysall, K., Clegg, P., Fang, Y., Cremers, A., Emans, P., Welting, T. and Peffers, M. (2017) 'MicroRNA Profiling in Cartilage Ageing', International Journal of Genomics. doi: 10.1155/2017/2713725. Feng, S., Bowden, N., Fragiadaki, M., Souilhol, C., Hsiao, S., Mahmoud, M., Allen, S., Pirri, D., Ayllon Tardajos, B., Akhtar, S., Thompson, A. A. R., Jo, H., Weber, C., Ridger, V., Schober, A. and Evans, P. C. (2017) ‘Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites’, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), pp. 2087–2101. doi: 10.1161/ATVBAHA.117.309249. Marsh, S. A., Arthur, H. M. and Spyridopoulos, I. (2017) ‘The secret life of nonclassical monocytes’, Cytometry Part A, 91(11), pp. 1055–1058. doi: https://doi.org/10.1002/cyto.a.23280 Gleeson, P. J., Wilson, V., Cox, T. E., Sharma, S. D., Smith-Jackson, K., Strain, L., Lappin, D., McHale, T., Kavanagh, D. and Goodship, T. H. J. (2016) ‘Chromosomal rearrangement—A rare cause of complement factor I associated atypical haemolytic uraemic syndrome’, Immunobiology. (SI: XXVI ICW Kanazawa 2016), 221(10), pp. 1124–1130. doi: 10.1016/j.imbio.2016.05.002. Lawrence, H., Deehan, D. J., Holland, J. P., Anjum, S. A., Mawdesley, A. E., Kirby, J. A. and Tyson-Capper, A. J. (2016) ‘Cobalt ions recruit inflammatory cells in vitro through human Toll-like receptor 4’, Biochemistry and Biophysics Reports, 7, pp. 374–378. doi: 10.1016/j.bbrep.2016.07.003. Lawrence, H., Mawdesley, A. E., Holland, J. P., Kirby, J. A., Deehan, D. J. and Tyson-Capper, A. J. (2016) ‘Targeting Toll-like receptor 4 prevents cobalt-mediated inflammation’, Oncotarget, 7(7), pp. 7578–7585. doi: 10.18632/oncotarget.7105.

iCASE05_2024: Skeletal muscle-blood vessel crosstalk drives muscle pathology during heart failure and diabetes (Prof Lee Roberts) iCASE07_2024: Precision medicine for treatment of VEXAS syndrome (Dr Sinisa Savic) iCASE09_2024: Hitting the target: creating tractable target proteins without losing function for the Biopharmaceutical Sector (Prof David Brockwell) iCASE10_2024: Save Our Souls: Allosteric inhibitors of Sos for targeting Ras-driven cancers using fragment-based drug discovery with structure-driven medicinal chemistry (Prof Alexander Breeze) iCASE25_2024: Channelling the “hole” story: future pandemic Coronavirus therapeutics through integrated understanding of virus-encoded ion channel electrophysiology (Prof Stephen Griffin) Standard01_2024: Developing an innovative approach for the detection of invasive fungal infections. (Dr Yoselin Benitez-Alfonso) Standard04_2024: Curing brain cancer one cell at a time: spatial, single cell transcriptomic analysis of glioblastoma brain tumour treatment response (Dr Lucy Stead) Standard05_2024: Alpha-synuclein amyloid in Parkinson's disease: using nanoinjection as a tool to study alpha-synuclein amyloid toxicity inside neurons(Dr Eric Hewitt) Standard08_2024: Could a ketogenic diet be used to treat glioblastoma? (Prof Richard Callaghan) Standard10_2024: The multifaceted role of CKS1 in multiple myeloma and new therapeutic frontiers in proteostatic targeting (Prof Gordon Cook) Standard12_2024: Antiviral nano medicine: a new approach to target emerging viral threats to human health (Dr Yuan Guo) Standard14_2024: Nanoscale structural mapping of protein aggregates in human disease (Dr Paolo Actis) Standard17_2024: Targeting the bacterial outer membrane as a new route to treat bacterial infections (Dr Antonio Calabrese) Standard19_2024: Seeing inside the Parkinson’s disease brain by in situ cryoET (Dr Rene Frank) Standard23_2024: Chemical probes for real-time visualisation of calcium-sensing receptor trafficking during inflammation (Dr Megan Wright) Standard25_2024: Biochemical and structural analysis of biomolecular condensates as reaction crucibles for neurodegeneration (Prof. Sheena Radford) Standard27_2024: Using wearable technology and biophysical measurements to personalise cancer therapy. (Dr Sharib Ali) Standard29_2024: You are only as old as your arteries – how targeting BACE1 in blood vessels could be the key to healthy aging (Dr Paul Meakin) Standard30_2024: Assessment of diabetic foot health using machine-learning to identify abnormal plantar load profiles (Prof Peter Culmer) Standard32_2024: Ubiquitin signalling regulation and inhibition in autoimmune disease (Prof Elton Zeqiraj) Standard40_2024: Using CRISPR screens to reveal the critical differences in radiotherapy and survival between HPV positive and HPV negative anal cancers (Prof Andrew Macdonald)

iCASE14_2024: Evaluation of novel therapeutics for the treatment of severe skin blistering adverse drug reactions (Dr Dan Carr). iCASE15_2024: Improving chemical and immunological assessment to drive safer development of the new breed of drugs: PROTACs. (Dr Xiaoli Meng) iCASE23_2024: Understanding how uveal melanoma cells render themselves invisible to- and manipulate the immune system to survive within the eye and liver. (Prof. Sarah Coupland) iCASE24_2024: Cardiovascular function around the clock: harnessing protective circadian mechanisms towards smarter design of novel retinoid therapies and lifestyle interventions. (Dr Vanja Pekovic-Vaughan) iCASE26_2024: Investigating synthetic teixobactins to tackle Multi-Drug Resistant MRSA Keratitis ( Dr Ishwar Singh) iCASE27_2024: Therapeutics for the next pandemic (Prof. James Stewart). Standard47_2024: Niemann-Pick type C (NPC) disease: full characterization of pH on megamitochondria engulfing lysosome (MMEL) under hypoxia. (Dr Massimiliano Stagi) Standard48_2024: Digital twins of clotting and lysis for precision medicine (Dr Wahbi El-Bouri) Standard58_2024: Matrix driven reprogramming of pancreatic cancer metabolism (Dr Tobias Zech) Standard61_2024: Seeking improved outcomes in pancreatic cancer: Applying multi-omic data analysis approaches to explore the biology underpinning pancreatic cancer-related diabetes. (Prof. Eithne Costello) Standard63_2024: Bioengineering a mucoadhesive composite for the delivery of chemotherapy to treat eye cancer. (Dr Victoria Kearns) Standard69_2024: Molecular mechanisms underlying age-related repair deficiencies of axonal microtubules: is EB1 phosphorylation the key? (Dr Igor Barsukov) Standard70_2024: Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia.. (Dr Manolis Papamichos Chronakis) Standard73_2024: Ageing, epilepsy, and the microtubule cytoskeleton: a novel trio in brain research. (Dr Natalia Sanchez Soriano) Standard74_2024: Designing Early Detection AI Diagnostic Tools for Age-related Macular Degeneration (Dr Ceniz Zihni) Standard75_2024: Using Deep Learning-based tools to better understand the interactions of viral proteins with host cells (Prof. Dan Rigden). Standard77_2024: Understanding thrombotic events in atrial fibrillation: how do neutrophil extracellular traps (NETs), cell-free histones and DNA contribute to poor outcomes. (Dr Simon Abrams)

iCASE03_2024: Targeting complement component 5 to reduce neuroinflammation and treat Alzheimer’s disease with new chemical and microscopy tools. (Dr Adam Wollman) Standard82_2024: The nucleolus in the mammalian oocyte; form or function (Dr Suzanne Madgwick) Standard83_2024: Investigating the adaptive resistance of Pseudomonas aeruginosa raised from antibiotic persistence (Dr Chien-Yi Chang) Standard84_2024: The role of the human microbiome and lifestyle in colorectal cancer (Prof Colin Rees) Standard86_2024: How does a single microRNA control bone turnover? (Prof. David Young) Standard87_2024: Why do autoimmune diseases relapse and remit? Investigating the role of antigen-specific B cells (Prof. Simon Pearce) Standard89_2024: Stopping superbugs sleeping cells: revealing molecular machines of sporulation at atomic level. (Professor Paula Salgado). Standard91_2024: Targeting the consequences of expressing the wrong cell-type specific genes in leukaemia (Dr Lisa Russell) Standard92_2024: Uncovering the role of the chromatin remodelling enzyme SET1B in the cellular response to hypoxia and inflammation. (Dr Brian Ortmann). Standard93_2024: Finding the sweet regulators of immunotherapy resistance in prostate cancer (Dr Emma Scott) Standard97_2024: Kinase inhibition reverses glucocorticoid resistance through upregulation of the glucocorticoid receptor transcriptional programme in acute lymphoblastic leukaemia. (Dr Frederik van Delft) Standard98_2024: Dissecting the molecular mechanisms driving antifungal drug resistance and immune evasion in an aged Candida albicans population. (Dr Alessandra Da Silva Dantas) Standard100_2024: Gaining insights from epidemiology, advanced analytics and big data to develop preventive strategies to improve health outcomes in ageing and multimorbidity. (Dr Dexter Canoy) Standard103_2024: Leveraging real-world patient survival data to identify novel therapeutic drug targets for acute myeloid leukaemia (Prof. James Allan) Standard106_2024: In vivo modelling to develop novel therapies against neurocognitive deficits in childhood cancer survivors (Dr Debbie Hicks) Standard111_2024: Metabolic barcoding of microbial antibiotic exposomes (Dr Katherine Duncan). Standard112_2024: Dissecting the role of microglia in type I interferon-mediated neurological disease (Dr Christopher Duncan). Standard115_2024: Stress response and resilience for longevity: sex and mitochondria (Dr Satomi Miwa) Standard124_2024: Establishment of models of aberrant ALK regulation during normal human sympathetic nervous system development. (Prof. Deborah Tweddle) Standard126_2024: Drawing the line between life and death: the role of DNA damage in Staphylococcal infections. (Dr Charles Winterhalter)

iCASE17_2024: Enabling safe and efficient generation of stem cell-based therapies (Prof. Ivana Barbaric) Standard129_2024: Imaging single base-pair damage on single molecules to find out how exactly radiotherapy and chemotherapies work. (Dr Helen Bryant). Standard130_2024: Deconvoluting the spatial multi-omic landscape of high-grade glioma to target post-surgical residual disease. (Dr Spencer Collis) Standard132_2024: Understanding the role of extracellular matrix remodelling in ovarian cancer metastasis (Dr Elena Rainero) Standard134_2024: Understanding the mechanisms associated with mitochondria dysfunction underpinning both age-related hearing loss and neurodegenerative diseases. (Prof. Walter Marcotti) Standard135_2024: Targeting the DNA damage response to overcome cancer dormancy and chemotherapy-resistance (Dr Alanna Green) Standard137_2024: Understanding S. pneumoniae penicillin resistance through the development of c-di-AMP capture and biosensor compounds (Dr David Williams) Standard138_2024: Optogenetic modeling of a hallmark neurodegeneration pathology for mechanistic research and drug discovery. (Dr Tatyana Shelkovnikova) Standard139_2024: Decoding Protein Dysfunctions in Alzheimer's Disease: Unravelling Mechanisms and Exploring Therapeutic Strategies. (Dr Suman De) Standard141_2024: Brain and bone: deciphering the connection [BRONE Study] (Dr Meena Balasubramanian) Standard142_2024: Development of novel cold atmospheric plasma-mediated drug delivery for targeted anti-cancer therapy (Dr Helen Colley) Standard144_2024: Neuroepigenetic augmentation of kinesin function as an anti-ageing treatment for neurons. (Dr Alison Twelvetrees) Standard148_2024: Targeting Salmonella subversion of cellular senescence to combat antimicrobial-resistant typhoid fever (Dr Daniel Humphreys) Standard150_2024: Developing novel gene therapy approaches to inhibit the unconventional translation of neurotoxic dipeptide-repeat proteins in pre-clinical models of C9ORF72-ALS/FTD (Prof. Guillaume Hautbergue) Standard151_2024: Functional biomechanical assessment of treatment efficacy in Amyotrophic lateral sclerosis (Prof. Christopher McDermott)

iCASE18_2024: The ubiquitin-proteosome system and drug discovery for leishmaniasis. (Prof. Jeremy Mottram) iCASE19_2024: Engineered Magnetic Nanoparticles for Targeted Delivery of Therapeutic Proteins (Prof Victor Chechik) iCASE22_2024: Clinical movement markers of osteoarthritis for treatment with regenerative medicine (Dr Adar Pelah) iCASE28_2024: Exploring cancer transcriptomes with Nanopore long-read sequencing (Prof. Dimitris Lagos) Standard155_2024: Illuminating the Future of Breast Cancer Therapeutics: Applying Synthetic Biology's UV Crosslinking Amino Acids for Drug Target Discovery. (Dr Andrew Holding) Standard157_2024: Targeting the ionic tumour microenvironment: repurposing sodium channel blocking antiarrhythmic drugs to suppress breast cancer metastasis (Dr William Brackenbury) Standard158_2024: Bioelectronics and bioelectricity of cancer cells: developing a platform to investigate the role of ion channels using organic bioelectronics and high-content image analysis. (Dr Stuart Higgins) Standard160_2024: Who shakes hands with the enemy? Discovering which subsets of mesenchymal stromal cells support acute lymphoblastic leukaemia (ALL) cell growth in the bone marrow. (Prof. Adele Fielding) Standard161_2024: A therapeutic molecular toolbox to control CKS1 in healthy and malignant stem cells (Dr Christopher Spicer). Standard163_2024: Targeting antibiotic resistance: anatomy of a genome maintenance machine at the biology-physics interface (Professor Daniela Barillà) Standard165_2024: Tissue regeneration using nano-biologics. Prof Paul Genever Standard171_2024: Precision assessment of human spatial memory: application to early detection of Alzheimer’s Disease (Dr Tom Hartley). Standard173_2024: New Experimental Approaches for Understanding Blood Cancers (Prof. David Kent) Standard175_2024: Utilising cellular antioxidant adaptations to develop colorectal cancer theranostics. (Dr Sangeeta Chawla) Standard176_2024: Understanding spatio-temporal GSK-3β activity in hematopoietic stem cells to improve regenerative medicine. (Dr Ines Hahn) Standard177_2024: Engineering mosquitoes to provide no-cold-chain delivery of vaccines . (Prof Luke Alphey) Standard179_2024: Discovery of new immunoregulatory signalling pathways to treat autoimmunity, infectious disease, and cancer. (Prof Gavin Wright)

You need to apply for three projects. We recommend you keep an open mind when choosing projects and contact the supervisors before submitting your application to discuss their research in more detail and inform your decision. If you are shortlisted to the interview stage, we will ask you to rank projects in order of preference.

All international applicants are required to have an internationally recognised English language qualification such as IELTS or equivalent. This does not need to be submitted at time of application but we recommend obtaining the qualification as soon as possible, the minimum standard within our partner institutions is an overall IELTS grade of 6.5 with a minimum of 6.0 in each component, or equivalent.

The majority of projects advertised are feasible part-time, however not all of them due to the specific experimental work commitments and you would need to discuss this as an option with the supervisory team before applying. International students must also consider UK Visas and Immigration (UKVI) restrictions and contact the host university international office for advice. Part-time study can only be at 50% of full time, so our 4 year programme would be spread over 8 years and stipend funding at 50% per payment. This has implications on Council tax as part-time students are no longer exempt. It is possible to switch to part-time during your PhD according to personal circumstances and this is reviewed locally, on a case-by-case basis.

We accept applications from UK and International applicants, however due to MRC funding conditions, awards to non-UK residents are capped at 30% per intake year (up to 12 places). To be classed as a home student, candidates must meet the following criteria: • Be a UK National (meeting residency requirements), or • Have settled status, or • Have pre-settled status (meeting residency requirements), or • Have indefinite leave to remain or enter If a candidate does not meet the criteria above, they would be classed as an International student.

We welcome applications from international candidates. If successful, international students will receive additional funding to cover the international tuition fees for the full 4 years. Please be aware there will be additional costs for your Visa application, UK healthcare cover and international travel that we do not provide as standard. Once an offer is made, these can be discussed with the supervisory team and reviewed on a case-by-case basis.